With the setup prompt screen on first boot, a number of things can be set up:
Locale Set to US English.
Keyboard Select 105 Generic, US layout
Expand to size of media
Enable Camera, SPI, and GPIO if need be thru special menus.
Additionally after first boot, this page shows how to enable NFS and CIFS mounting if it is not already in the default. Originally the images did not have SMB (CIFS) file system support, and it had to be added.
Also optionally NFS and NFS server can be installed.